Modalert 200 is generally considered safe for long-term use when taken as prescribed and under the guidance of a healthcare professional. It has been extensively studied and has a well-established safety profile. However, it's important to regularly monitor your health and discuss any concerns with your doctor. Long-term use may require periodic evaluations to assess the ongoing need for the medication and monitor for any potential side effects or interactions. As with any medication, individual responses may vary, and it's essential to follow the recommended dosage and guidelines provided by your healthcare provider to ensure the safest and most effective use of Modalert 200.